Peptide Chronicles: Tirzepatide

Mar 25, 2025 | Peptide Chronicles | 0 comments

By Steve

Tirzepatide – Actions & Benefits

Tirzepatide (brand name Mounjaro) is a dual GLP-1 and GIP receptor agonist, primarily used for type 2 diabetes management and weight loss. It has shown superior weight loss effects compared to Semaglutide (Ozempic/Wegovy).


Actions of Tirzepatide

  1. GLP-1 Receptor Activation (Glucagon-Like Peptide-1)
    • Increases insulin secretion to lower blood sugar.
    • Suppresses glucagon release, reducing blood sugar spikes.
    • Slows gastric emptying, increasing satiety and reducing food intake.
  2. GIP Receptor Activation (Glucose-Dependent Insulinotropic Polypeptide)
    • Enhances insulin sensitivity, making the body more efficient at using glucose.
    • Works synergistically with GLP-1 to boost metabolic function.
    • May help preserve lean muscle mass during weight loss.

Benefits of Tirzepatide

Superior Weight Loss – Clinical trials show up to 22.5% body weight reduction, making it more effective than Semaglutide.
Enhanced Blood Sugar Control – Lowers A1C levels significantly for diabetes management.
Greater Appetite Suppression – Reduces hunger and cravings more effectively than GLP-1 agonists alone.
Improved Fat Metabolism – Helps burn fat while preserving muscle mass.
Cardiovascular Protection – Lowers blood pressure, cholesterol, and overall heart disease risk.
Potential Longevity & Metabolic Health Benefits – May support anti-aging, neuroprotection, and inflammation reduction.

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